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^,,,,a,,,,b,,,,c,,,,d,,,,e,,,,f,,,,g,,,,h,,,,i,,,,j,,,,k,,,,l,,,,Irwin,,,,&,,,,RippeThe,,,,most,,,,popular,,,,hypothesis,,,,by,,,,Deitch,,,,to,,,,explain,,,,MODS,,,,in,,,,critically,,,,ill,,,,patients,,,,is,,,,the,,,,gut,,,,hypothesis.[4],,,,Due,,,,to,,,,splanchnic,,,,hypoperfusion,,,,and,,,,the,,,,subsequent,,,,mucosal,,,,ischaemia,,,,there,,,,are,,,,structural,,,,changes,,,,and,,,,alterations,,,,in,,,,cellular,,,,functionJAMASubsequently,,,one,,might,,see,,liver,,failure,,(57,,days),,,gastrointestinal,,bleeding,,(1015,,days),,and,,kidney,,failure,,(1117,,days).[1]Horn&,,Look,,Inside,,Get,,Access,,Chapter,,Pages,,131-133,,Untimely,,Apoptosis,,in,,Human,,SIRS,,,SEPSIS,,,and,,MODS,,Timothy,,GSign,,in,,to,,access,,your,,subscriptions,,Sign,,in,,to,,your,,personal,,account,,Create,,a,,free,,personal,,account,,to,,access,,your,,subscriptions,,,sign,,up,,for,,alerts,,,and,,more,,Purchase,,access,,Subscribe,,to,,Learning,,for,,one,,year,,Buy,,this,,activity,,(2014)PMID17171483Goris,,,Look,,,Inside,,,Get,,,Access,,,Chapter,,,Pages,,,82-85,,,Cardiopulmonary,,,Bypass,,,for,,,Cardiac,,,Surgery:,,,An,,,Inflammatory,,,Event:,,,Can,,,It,,,Be,,,Modulated?,,,Arthur,,,EBuchman,,Look,,Inside,,Get,,Access,,Chapter,,Pages,,134-142,,Immunosuppression,,with,,Injury,,and,,Operation,,and,,Increased,,Susceptibility,,to,,Infection,,Eugen,,Faist,,,Martin,,K

Mortality,,,varies,,,from,,,30%,,,to,,,100%,,,where,,,the,,,chance,,,of,,,survival,,,is,,,diminished,,,as,,,the,,,number,,,of,,,organs,,,involved,,,increasesUsing,,,,similar,,,,physiologic,,,,variables,,,,the,,,,Multiple,,,,Organ,,,,Dysfunction,,,,Score,,,,was,,,,developed.[1]Department,,,of,,,Surgery,,,,Klinikum,,,Grosshadern,,,,University,,,of,,,Munich,,,3It,,usually,,involves,,two,,or,,more,,organ,,systems.[1]Sepsis,,may,,result,,in,,septic,,shockThe,,authors,,assessed,,the,,level,,neutrophil,,infiltration,,in,,lung,,and,,liver,,tissue"Rs1800625,,,,in,,,,the,,,,receptor,,,,for,,,,advanced,,,,glycation,,,,end,,,,products,,,,gene,,,,predisposes,,,,to,,,,sepsis,,,,and,,,,multiple,,,,organ,,,,dysfunction,,,,syndrome,,,,in,,,,patients,,,,with,,,,major,,,,trauma"Liver,,,,dysfunction,,,,leads,,,,to,,,,toxins,,,,escaping,,,,into,,,,the,,,,systemic,,,,circulation,,,,and,,,,activating,,,,an,,,,immune,,,,responseHowever,,,in,,one-third,,of,,the,,patients,,no,,primary,,focus,,can,,be,,found.[1],,Multiple,,organ,,dysfunction,,syndrome,,is,,well,,established,,as,,the,,final,,stage,,of,,a,,continuum:,,SIRS,, ,,infection,,sepsis,,severe,,sepsis,,Multiple,,organ,,dysfunction,,syndrome.

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